Phenylethanolamine N-methyltransferase



Phenylethanolamine N-methyltransferase (PNMT) catalyzes the conversion of norepinephrine (noradrenaline) to epinephrine (adrenaline). This is the last step in the conversion of tyrosine to adrenaline. S-adenosyl-L-homocysteine (AdoHcy) by itself or with other ligands are inhibitors of PNMT. The images at the left and at the right correspond to one representative PNMT, i.e. the crystal structure of Phenylethanolamine N-methyltransferase (3kpj).

3D Structures of Phenylethanolamine N-methyltransferase
3kpj – hPNMT+AdoHcy – human

3kpu, 3kpv, 3kpw, 3kpy, 3kqm, 3kqo, 3kqp, 3kqq, 3kqs, 3kqt, 3kqv, 3kqw, 3kqy, 3kr0, 3kr1, 3kr2, 3hcb, 3hcc, 3hcf, 2ony, 2g70, 2g71, 2g8n, 2an5, 1yz3, 1n7i, 1n7j, 1hnn - hPNMT+AdoHcy+ligand

3hca, 3hce, 2obf, 2onz, 2obp - hPNMT (mutant)+AdoHcy+ligand

3hcd - hPNMT+AdoHcy+noradrenaline

2g72 - hPNMT+AdoMet+ligand

2an3 - hPNMT+AdoHcy+substrate analog

2an4 - hPNMT+AdoHcy+octopamine